Data from the first international Multicenter Selective Lymphadenectomy Trial (MSLT-I) and the screening-phase of the second trial (MSLT-II) were analyzed to determine the association of smoking with clinicopathologic variables and SLN metastasis.
Current smoking was strongly associated with SLN metastasis, even after adjusting for other predictors of metastasis. Among 4231 patients current or former smoking was also independently associated with ulceration. Compared with current smoking, never smoking was independently associated with decreased Breslow thickness in multivariate analysis and with a 0.25 mm predicted decrease in thickness.
The direct correlation between current smoking and SLN metastasis of primary cutaneous melanoma was independent of its correlation with tumor thickness and ulceration. Smoking cessation should be strongly encouraged among patients with or at risk for melanoma.
Don't smoke, guys! Just. Don't! - c