We already know that folks who get immunotherapy WITH (or as soon as possible relative to) SRS [stereotactic radiation] therapy for brain mets do best. Here's a post with multiple links that covers that and then some: Anti-PD-1 works best with SRS for brain mets in melanoma, Don't wait to add anti-PD-1 to SRS for brain mets, etc, etc!!!!!
Yet, patients are STILL being advised BY THEIR ONCOLOGISTS, "Oh, my goodness, no!! We can't do both immunotherapy and SRS to brain mets at the same time.! It would be too toxic. It would increase the risk of radiation necrosis!"
Now, radiation necrosis is a real problem. It is a complication that arises for far too many. However, combining radiation with immunotherapy does NOT increase the risk! Check out this review of 137 patients and their 1,094 brain lesions:
Could we get some nit-wit oncologists/radiation oncologist to read their own professional journals....or this blog? Well, if you get told something similar to the little talk outlined above....PRINT and DELIVER this report to them! Hang tough, dear ratties! - c