BRAF inhibitors combined with MEK inhibitors have been an amazing targeted treatment option for BRAF positive melanoma patients (about half of us). They rarely have durable responses, though occasionally they can remain effective therapy for years, but are incredibly useful in our treatment arsenal.
Here is a post that gives a basic primer on BRAF and targeted therapy: BRAF inhibitors for melanoma
Here is a post on several BRAF/MEK combo's The coBRIM trial with links to other reports
And of course....there are always side effects. Here is a report from Weber and Agarwala: Side effects and how to manage them
Now there is this with specific plans re management of adverse events.....
|Recommended dosage adjustments....|
|Management of fever...|
|Management of rash....|
|Management of cardiac side effects....|