Sunday, October 22, 2017

Cancer and Sugar!! Oh, lordy, lordy! Here we go again!!!


As I've said about a zillion times before, if we ever find one food, one activity, one thing...that cures cancer or prevents a person from developing cancer...I will more than happily abstain from that thing!!!  And should it come down to sugar and cancer, that will be a pretty easy deal for me.  I rarely eat sweets...not because I'm a saint, think they will make me fat, or because I think they are bad for me.  NOPE!  I just don't like them that much.  I'd much rather have a piece of cheese!!!  That being the case, what I've also said a zillion times before is much more important:  No matter what we eat ~ a piece of cake, cheese, dandelion greens, steak, pasta, or anything else....our body turns it all - ALL OF IT - into GLUCOSE - the only fuel our cells can use!!!

Why am I going over this tired old ground again???  Because a "new" article is out and I am trying to stay ahead of the curve!!! 

With great thanks to my partner in crime, hiking, research, and life:

B writes, "There is a new article in Nature Communication which makes a connection  between abnormal sugar utilization in cancer cells and the mechanism whereby the same metabolic pathway in yeast cells causes an excessive growth of the yeast cells.  It presumes that the same mechanism is present in both yeast and mammalian cancer cells.  There is far from any evidence that the intake of normal amounts of sugar in people would exacerbate the growth of cancer cells in humans.  Even the author of the study points this out."

Here's the original (rather obtuse) article, from Nature Communications:  Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras

Here's a press release that is more accurate, from Bruce Vanderburg, in Reliawire :  Link Between Cancer Tumour Growth And Sugar Clarified

And finally, there's this press release which is more dramatic and WRONG, By Najja Parker, The Atlanta Journal-Constitution:  Study: Sugar can fuel cancerous cells
(#sorrynotsorry Najja!!  #itiswhatitis)

So, there you go.  Take it as you will.  If you wish to abandon the intake of sugar.  FINE!!  You may well experience some weight loss and various other health benefits (like maybe filling up on more veggies - or - better glucose control, especially if you have diabetes or a family predisposition for that disease) but, unfortunately, thus far, there is no data to show that it will prevent or cure your cancer.

Take it as you will!!!  Wishing you all our best! - b and c

Travel Chaotically! - Fall begins to come to the mountains


While I LOOOOOOVE traveling....pretty much anywhere!!!!! - I try to make sure I take the time to appreciate and enjoy my home!!!  (Well, 2 hours away from my actual home...but you get the idea!)  So, earlier this week...B and I took a walk in the woods...Cades Cove, here in the Smoky Mountains...

It is hard to find a walk, ANYWHERE in the world, that is prettier than along the Middleprong.

Beauty in things great...

...and small.



My hiking buddy on Bote Mountain Trail...no bears today!

Color is just creeping in...

...but how beautiful is this brown and white number?


"I think that I shall never see a poem as lovely as a tree...."


Beauty.  Nature.  Best friends.  Stopping to smell the moss and open my eyes to the world around me.  A new report concludes that pollution is linked to 9 million deaths world wide.  Four American heroes were killed in Niger.  One billion people are currently suffering from hunger across the globe.  More than 87,000 folks will be diagnosed with melanoma in 2018 in the U.S. alone.   A flipping hurricane hits Ireland.  Acres and acres...of HOMES....not forest...burned in California.  American citizens are without clean (much less running) water and power in Puerto Rico.  Still.  More than a month after the hurricane that struck the island.  Healthcare is at risk in America.  Men with power continue to abuse it and those around them.  We need to do better.  We CAN do better!! But if you need to re-set, re-group, re-charge....take a walk in the woods.  Then ~ we begin again!!! - love, les

Friday, October 20, 2017

Lymphocyte-to-monocyte ratio associated with survival in melanoma patients treated with pembrolizumab (Keytruda)


Learning how well we are responding to a melanoma therapy or even predicting that response with a simple blood test would be sooooooooooooo AWESOME!!!!  Researchers have been looking at various lab values in that regard.  Here are some of the articles I've posted on the topic:

2015: Lab values that may predict response to Ipi/Yervoy????
2016: Biomarkers - blood components, circulating tumor cells AND of the tumor itself
Blood markers associated with clinical outcome of melanoma treated with ipi
2017: Eosinophilia - biomarker for prognosis in melanoma and importance in immunotherapy response

Now, there's this:

Lymphocyte-to-monocyte ratio is associated with survival in pembrolizumab-treated metastatic melanoma patients. Failing, Yan, Porrata, Markovic. Melanoma Res. 2017 Oct 9.

The peripheral blood lymphocyte-to-monocyte ratio (LMR) has been associated with prognosis in many malignancies including metastatic melanoma. However, it has not been studied in patients treated with immune checkpoint inhibitors. In this study, we analyzed the baseline LMR with progression-free survival (PFS) and overall survival (OS) in metastatic melanoma patients treated with pembrolizumab. A total of 133 patients with metastatic melanoma treated with pembrolizumab were included in this retrospective study. LMR was calculated from pretherapy peripheral blood counts and the optimal cutoff value was determined by a receiver operator characteristic curve. PFS and OS were evaluated using the Kaplan-Meier method and multivariate Cox proportional hazard modeling. Patients with an LMR of at least 1.7 showed improved PFS and OS. The baseline LMR is associated with PFS and OS in metastatic melanoma patients treated with pembrolizumab, and could represent a convenient and cost-effective prognostic biomarker. Validation of these findings in an independent cohort is needed.
Every bit of intel helps!!  Hang tough, ratties!! - c

Thursday, October 19, 2017

Travel Chaotically! - Paris 4 - Jardin des Tuilleries and Musee de l'Orangerie


Me and B...another day of Paris wanderings!



In a me-made B had already dubbed "The Paris Dress"!
Only doing their job, I'm sure...but not exactly comforting!

The strange ...
...juxtapositions...

...of life!












Me and B....in a parallel doggie universe!

Monet!
The Water Lilies....are so incredibly displayed....



...in the Musee de l'Orangerie.















Art....












...has many faces.

                                                                     
I love B's eye...and this chic's shoes!





























Another lovely day in Paris.... (More on the completion of these wanderings as we traveled to Bordeaux, Sarlat, Marseilles later!!)   Travel Chaotically!!! ~ les