On the subject of intratumoral treatment of melanoma - drugs that are injected directly into the tumor, as the prior post on IMO-2125, a TLR agonist discussed, along with ALL these other intralesional/intratumoral therapies covered here: ASCO 2017: All things intralesional/intratumoral
- we've learned a couple of things:
1. These drugs can have significant "by-stander" effect. Meaning - they can kill not only the tumor they are injected it...but others...distant from the site of the injected tumor.
2. As many melanoma experts said years ago, they will most likely turn out to be most effective when paired with systemic immunotherapy (as most of the research that is on-going is doing currently.
But...there's another one on the horizon. It's been a long time in coming. I posted this back in 2014:
CD40 Antibody therapy for melanoma....another way to activate the immune system?
And now, there's this:
Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain. Singh, Vianden, Cantwell, et al. Nat Commun. 2017 Nov 13.
Fingers crossed, ratties! Fingers crossed. - c