We have long known that melanoma patients with brain mets respond better to SRS than WBRT.
For review here are a zillion posts about brain mets in melanoma.
There is this from the European Cancer Conference....
I am not clear on exactly what the authors mean by the msGPA (probably an assessment tool they have created), but what remains clear is that SRS and systemic therapy serve patients much better than those who were treated with whole brain radiation alone. And if you recall, in this recent post: SRS with any systemic therapy helps response in melanoma...but anti-PD-1 WITH SRS = best OS in brain mets
Researchers reported: Ipi with SRS = 7.5 month OS. BRAF/MEK with SRS = 17.8 months OS. Anti-PD-1 with SRS = 20.4 month OS.
We need to LIVE and learn....no more interferon....no more WBRT!!! Ratties have provided the proof. Let's make sure no other melanoma peeps have to suffer needlessly!!! - c