Despite a heavy heart, I begin my annual journey through the ASCO reports. Great thanks to B for funneling the most pertinent of the entire meeting my way. I will do my best to give you the unvarnished abstracts, any relevant history I have, and my take on what the expert's jargon is really saying. As usual, my commentary will be in red. However, there are many sources through which you can read them (as well as see videos) for yourself and I certainly encourage you to do so. At any rate, in honor of Jamie and Josh - here we go....
Can you get a response to nivo (Opdivo) alone or the ipi/nivo combo after you've been treated with ipi or anti-PD-1 and progressed????? Yes, you can!!!!!
Here patients who have poor prognostic factors as well as progression after ipi are treated with nivo alone:
|Total pt (n=734)||ECOG PS 2 (n=48)||Uveal (n=75)||Mucosal (n=52)||CNS (n=112)|
|response rate at 12 weeks, % (n)||32 (123/386)||15 (2/13)||6 (2/34)||21 (5/24)||43 (20/47)|
|Med OS (mo)||19 (17-NR)||2 (1-4)||11 (7-15)||13 (6-NR)||13 (9-NR)|
|1-yr OS rate, %||63 (60-67)||14 (2-26)||47 (34-59)||53 (38-67)||51 (40-60)|
While response rates were not nearly what we'd like them to be, patients DID respond to both nivo after ipi and the Ipi/Nivo combo after prior treatments of ipi and anti-PD-1 alone. Side effects were no worse than what we already know them to be on the respective immunotherapies. Hang tough ratties. Much love and hope to each of you. - c