Y'all know I've been yelling about combining radiation WITH immunotherapy for YEARSSSSS...
Here's a link to about 10 zillion posts: Radiation and immunotherapy in melanoma
Here, hypofractionated radiotherapy (multiple small doses of radiation) is combined with anti-PD-1 as a single agent ~
Lesions that were radiated showed: CR = 24% , PR = 8% , S = 44%, P = 28%.
Lesions not treated with radiation: CR = 29%, PR = 19%, S = 19%, P = 33%.
"Among pts radiated late for insufficient response to anti-PD-1 monotherapy, CR or PR in non-radiated lesions (i.e. abscopal response) was observed in 56% of pts."
That abscopal shit be real, y'all!!!! Thanks ratties! - c