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Vasculitic Neuropathy induced by Pembrolizumab. Aya, Ruiz-Esquide, Viladot, et al. Ann Oncol. 2016 Nov 17.
Atrophic Exocrine Pancreatic Insufficiency Associated with Anti-PD1 Therapy. Long, Hoadley, Sandanayake. Ann Oncol. 2016 Nov 17.
Autoimmune Cardiotoxicity of Cancer Immunotherapy. Cheng, Loscalzo. Trends Immunol. 2016 Dec 2.
Contemporary immunotherapies (e.g., immune checkpoint inhibitors), which enhance the immune response to cancer cells, improve clinical outcomes in several malignancies. A recent study reported the cases of two patients with metastatic melanoma who developed fatal myocarditis during ipilimumab and nivolumab combination immunotherapy; these examples highlight the risk of unbridled activation of the immune system.
Not trying to alarm anyone!!! With melanoma you gotta get treatment! And sadly, knowledge of side effects cannot necessarily prevent them. Still, forewarned may allow you to be forearmed in recognizing a problem so that it can be dealt with before it causes additional harm!
All my best, c