FDA Press release re: Atezolizumab
Hopefully this will give folks dealing with bladder (and related) cancers some relief and cures!!! It is being tested in melanoma world as well. Remember this from Weber's update?
Immunology up-date/webinar by Weber 2016
There he said this:
Cohorts: 1- atezo and vemurafenib together 2- vemurafenib X 56 days followed by atezo
3- vemurafenib X 28 days followed by Atezo. Atezolizumab (an anti PD-L1 anti-body) was given IV q 3 wk at 20 or 15 mg/kg and Vemurafenib was BID at 960 mg during run in, then decreased to 720mg bid.
Confirmed overall response rate: Cohort 1 - 33%, Cohort 2 - 75 %, Cohort 3 - 100%. Overall 76% response rate. Median of 12.2 months. AE's were manageable with no grade 4. Additive activity with excellent level of response. You will hear much more about this combo in the future.
Hang in there, ratties of all stripes!!! Working together we help each other....and...times they be a changing!!! - c