Having developed brain and lung mets in 2010, I was unceremoniously thrust from my 2003 Stage 3b melanoma diagnosis to Stage IV! I got busy ~ zapping the brain met and removing the upper lobe of my lung to rid myself of the melanoma there. Then...nothing. There were no FDA approved drugs for melanoma available (other than interferon...so, yeah. Nothing.). No BRAFi, ipi, much less anti-PD1. Trials were practically nonexistent, because, as I quickly discovered, almost all of them required "measurable disease", something I had just gone to a great deal of trouble to rid myself of!!!! Through perseverance, almost endless computer searches and phone calls bordering on the level of insanity, B did find one trial for which I qualified - the NED arm of a Phase 1 Nivo/vaccine trial at Moffit. (This was back when Nivolumab, now Opdivo, was known as MDX1106 and I was certain melanoma was going to kill me!!) Despite how well I and my fellow ratties have done for the most part (blessings and sorrow for those who did not fare as well) adjuvant treatments for melanoma patients are still hard to find. It should not be this way!!!
Here is one recent post addressing "progress" for NED melanoma patients as well as a link to the results of my NED/nivo study: Surgical management and adjuvant therapy for high risk melanoma - still waiting for answers!!