Thursday, October 16, 2014

Slides from Paris Melanoma Meeting addressing ipi combos


Covering much of the same territory as my prior post  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/09/weber-presentation-on-present-ipi.html
However, this presentation is in slide form, allowing you to see the data a bit differently.  Here is a synopsis with presentation linked below:

For ipi and nivo...combo or sequential:
  • 43% ORR with 17% CR's and 82% in remission for all concurrent ipi/nivo patients
  • 62% grade 3-4 AEs (LFTs, lipase, amylase, rash, colitis)
  • BRAF status, PD-L1 tumor staining NOT associated with response
  • Response in sequential patients associated WITH ipi PK levels prior to starting anti-PD1
  • Concurrent 2 yr OS 79% = "IMPRESSIVE" 
Eval of T-VEC (Talmogene Laherparepvec) and ipi combo:
  • Unresected, untreated Stage IIIB/IV, 18 patients
  • 4 CR, 6 PR, 3 SD, ORR = 56%
  • Only 3 grade 3-4 AEs from ipi
  • Results may address the hypothesis that T-VEC may prime an immune response amplified by ipi
INCBO24360 and ipi:
  • Target inhibition of IDO achieved at 25-50mg BID
  • 33% RR and 33% stable disease
  • Toxicity = increased LFTs
  • Immunotherapy naive patients did best
  • 10 of 12 patients required no further therapy
Nivo in patients naive to OR progressed on ipi:
  • NO diff between ORR, PFS, and OS between ipi naive and ipi refractory patients [This is different from what studies have shown with Keytruda! More info on above post.]
  • High pretreatment MDSC (myeloid derived suppressor cells) increases in T-regs associated with poor outcome [better explanation of this on blog post linked above]
  • Perhaps combining anti-PD1 with MDSC or T-reg depletion would make it more effective

Paris Melanoma Meeting July 2014

Wishing all the ratties my very best! - c

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