As the search continues for ways to predict response and new avenues to attain a response in the treatment of melanoma - there is this:
VISTA expression on tumor-infiltrating inflammatory cells in primary cutaneous melanoma correlates with poor disease-specific survival. Kuklinkski, Yan, Li, et al. Cancer Immunol Immunother. 2018 May 8.
Adaptive
immune responses contribute to the pathogenesis of melanoma by
facilitating immune evasion. V-domain Ig suppressor of T-cell
activation (VISTA) is a potent negative regulator of T-cell function
and is expressed at high levels on monocytes, granulocytes, and
macrophages, and at lower densities on T-cell populations within the
tumor microenvironment. In this study, 85 primary melanoma specimens
were selected from pathology tissue archives and
immunohistochemically stained for CD3, PD-1, PD-L1, and VISTA.
Pearson's correlation coefficients identified associations in
expression between VISTA and myeloid infiltrate and the density of
PD-1+ inflammatory cells. The presence of VISTA was associated with a
significantly worse disease-specific survival in univariate analysis
and multivariate analysis. Our findings show that VISTA expression is
an independent negative prognostic factor in primary cutaneous
melanoma and suggests its potential as an adjuvant immunotherapeutic
intervention in the future.
Get busy researchers!!! - c
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