I've ranted and railed about the exclusion of ever so many groups in melanoma treatment...especially in trials - brain mets/CNS disease, previously treated, pre-existing autoimmune disease, other illnesses.... Sooooooo many times. Let's think this through shall we? What happens to untreated melanoma patients?????? Yep. Enough said!
I wrote this post regarding folks with preexisting autoimmune disease earlier this year:
Patients with preexisting immune disease, melanoma, and treatment with Anti-PD-1? Yes, this can be done. Yes, autoimmune flares should be treated with immunosuppressive therapy while on immunotherapy. And YES!!!! These patients can still attain a response!
While these patients certainly require close observation (Then again...don't all folks on immunotherapy???!!!), they can safely and effectively treat their melanoma with immunotherapy!!! Here's one more report: