Recruiting
|
A Phase II Study of Imatinib
Versus Interferon as Adjuvant Therapy in KIT-mutated Melanoma NCT01782508 For-Melanoma, Drug = Imatinib,
interferon
|
||||||||
Recruiting
|
A Study of the BRAF Inhibitor
Dabrafenib in Combination With the MEK Inhibitor Trametinib in the Adjuvant
Treatment of High-risk BRAF V600 Mutation-positive Melanoma After Surgical
Resection.
NCT01682083 For-Melanoma,
Drug = Dabrafenib, trametinib, placebo
|
||||||||
Recruiting
|
Adjuvant, Combined Interleukin 2
(Proleukin) and DTIC (Dacarbazine) in High-risk Melanoma Patients NCT00553618 For-Metastatic Melanoma, Drug =
Proleukin, Dacarbazine
|
||||||||
Recruiting
|
NCT02223819
For-uveal melanoma, Drug = crizotinib
|
||||||||
Recruiting
|
Adjuvant Dabrafenib (GSK2118436)
in Patients With Surgically Resected AJCC Stage IIIC Melanoma Characterized
by a BRAFV600E/K Mutation NCT01682213 For-Melanoma,
Drug = Dabrafenib
|
||||||||
Recruiting
|
Tumor Cell Vaccines and ISCOMATRIX
With Chemotherapy After Tumor Removal NCT01341496 For-sarcoma, melanoma
epithelial and pleural malignancies.
Drug = Modifies autologous tumor, cyclophosphamide, celecoxib
|
||||||||
Recruiting
|
Phase II/III Clinical Study CSF470
Plus BCG Plus GM-CSF vs IFN Alpha 2b in Stage IIB, IIC and III Melanoma
Patients
NCT01729663 For-cutaneous mel, Biological-CSF470 vaccine, BCG, molgramostim,
Drug-interferon alpha 2b
|
||||||||
Not yet recruiting
|
Study of Neoadjuvant Vemurafenib
for BRAF Mutant Melanoma and Palpable Lymph Node Metastasis NCT02036086 For-melanoma, Drug =
vemurafenib
|
||||||||
Not yet recruiting
|
NCT02068586,
For-ciliary body and choroid melanoma and intraocular mel,Drug-Sunitinib,
valproic acid
|
||||||||
Recruiting
|
BRIM8: A Study of Vemurafenib Adjuvant
Therapy in Patients With Resected Cutaneous BRAF Mutant Melanoma NCT01667419, For-mel, Drug = vemurafenib
|
||||||||
Recruiting
|
Ipilimumab for Uveal Melanoma NCT01585194, For-uveal mel, Drug,
ipi
|
||||||||
Recruiting
|
Messenger Ribonucleic Acid (mRNA)
Transfected Dendritic Cell Vaccination in High Risk Uveal Melanoma Patients NCT00929019, For-uveal mel, Drug
= autologous dendritic cells.
|
||||||||
Recruiting
|
NCT01543464,
For-malignant mel, Drug = chemo-temozolomide
|
||||||||
Recruiting
|
For-recurrent
mel, Stages 111B, IIIC, and IV. Drug =
ipi, recombinant interferon
|
||||||||
Recruiting
|
Phase I/II Trial of a Long Peptide
Vaccine (LPV7) Plus TLR Agonists NCT02126579, For-mel – metastatic
and mucosal. Drug = peptide vaccine LPV7+tetanus
peptide, polyICLC, Resiquimod
|
||||||||
Recruiting
|
For-uveal
mel, monosomy 3 positive, no mets.
Drug = autologous dendritic cells
|
||||||||
Recruiting
|
NY-ESO-1 Vaccine in Combination
With Ipilimumab in Patients With Unresectable or Metastatic Melanoma NCT01810016 For-unresectable
mel. Drug = ipi, NY-ESO-1protein
vaccine, NY-ESO-1OLP4 vaccine
|
||||||||
Recruiting
|
NCT01970358
For-mel, Drug = poly-ICLC peptides
|
||||||||
Recruiting
|
Trial of Ipilimumab After Isolated
Limb Perfusion, in Patients With Metastases Melanoma NCT02094391 For-in-transit mel
Stage IIIB and IIIC. Drug = ipi
|
||||||||
Recruiting
|
Safety and Immunogenicity Study of
Multi-phosphopeptide Vaccine Plus PolyICLC in Participants With Melanoma NCT01846143 For-mel,
Drug = biological phosphopeptides
|
||||||||
Recruiting
|
A Phase I Trial of a Vaccine
Combining Multiple Class I Peptides and Montanide ISA 51VG With Escalating
Doses of Anti-PD-1 Antibody Nivolumab or Ipilimumab With Nivolumab For
Patients With Resected Stages IIIC/ IV Melanoma NCT01176474 For – mel. Drug =
Nivo, ipi
{NOTE –
my trial….peptide vaccines no longer given}
|
||||||||
Recruiting
|
Vaccine Therapy and Resiquimod in
Treating Patients With Stage II-IV Melanoma That Has Been Removed By Surgery NCT01748747 For-mel, Drug =
montanide, MART 1 antigen
|
||||||||
Recruiting
|
NCT01308294.
For-mel, Drug = vaccine
|
||||||||
Recruiting
|
Neurotropic Melanoma of the Head
and Neck
NCT00975520, radiation
|
||||||||
Recruiting
|
Vaccination With Autologous
Dendritic Cells Loaded With Autologous Tumor Lysate or Homogenate Combined
With Immunomodulating Radiotherapy and/or Preleukapheresis IFN-alfa in
Patients With Metastatic Melanoma: a Randomized
"Proof-of-principle" Phase II Study NCT01973322 For-nonresectable
Stage III or IV mel, Drug = Autologous dendritic cell vaccines,
radiation, IFN
|
||||||||
Recruiting
|
CDX-1401 and Poly-ICLC Vaccine
Therapy With or Without CDX-301in Treating Patients With Stage IIB-IV
Melanoma
NCT02129075 For-ciliary body, choroid, extraocular, iris, intraocular,
mucosal mel or melanoma Stage IIB – IV Drug = recombinant flt3 ligand,
vaccine
|
||||||||
Recruiting
|
NCT01838200
For-metastatic mel, Drug = BCG vaccine, ipi
|
||||||||
Recruiting
|
Vaccine Therapy With or Without
Interleukin-12 Followed by Daclizumab in Treating Patients With Metastatic
Melanoma
NCT01307618 For-recurrent mel, stageIV.
Drug = peptide vaccine, MAGE-3.1 antigen, interleukin-12, Mart-1
antigen
|
||||||||
Recruiting
|
Trial of pIL-12 Electroporation
Malignant Melanoma
NCT01502293 For-mel, Drug=Plasmid interleukin-12
|
||||||||
Recruiting
|
Imiquimod to Detect Residual
Lesions and Prevent Recurrence of Lentigo Maligna NCT01088737 For-lentigo maligna,
Drug = imiquimod
|
Sunday, September 7, 2014
Studies listed as adjuvants for melanoma (including uveal, mucosal and ocular)....not advocating all of them, but adjuvant options are out there...forgive formatting, best I could do! Call the sites if interested!!!
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