Sunday, September 7, 2014

Studies listed as adjuvants for melanoma (including uveal, mucosal and ocular)....not advocating all of them, but adjuvant options are out there...forgive formatting, best I could do! Call the sites if interested!!!



Recruiting








Recruiting




Recruiting
Adjuvant, Combined Interleukin 2 (Proleukin) and DTIC (Dacarbazine) in High-risk Melanoma Patients   NCT00553618 For-Metastatic Melanoma, Drug = Proleukin, Dacarbazine




Recruiting
NCT02223819 For-uveal melanoma, Drug = crizotinib




Recruiting




Recruiting
Tumor Cell Vaccines and ISCOMATRIX With Chemotherapy After Tumor Removal NCT01341496 For-sarcoma, melanoma epithelial and pleural malignancies.  Drug = Modifies autologous tumor, cyclophosphamide, celecoxib




Recruiting
Phase II/III Clinical Study CSF470 Plus BCG Plus GM-CSF vs IFN Alpha 2b in Stage IIB, IIC and III Melanoma Patients NCT01729663 For-cutaneous mel, Biological-CSF470 vaccine, BCG, molgramostim, Drug-interferon alpha 2b




Not yet recruiting




Not yet recruiting
NCT02068586, For-ciliary body and choroid melanoma and intraocular mel,Drug-Sunitinib, valproic acid




Recruiting




Recruiting
Ipilimumab for Uveal Melanoma NCT01585194, For-uveal mel, Drug, ipi




Recruiting




Recruiting
NCT01543464, For-malignant mel, Drug = chemo-temozolomide




Recruiting
For-recurrent mel, Stages 111B, IIIC, and IV.  Drug = ipi, recombinant interferon




Recruiting
Phase I/II Trial of a Long Peptide Vaccine (LPV7) Plus TLR Agonists NCT02126579, For-mel – metastatic and mucosal.  Drug = peptide vaccine LPV7+tetanus peptide, polyICLC, Resiquimod




Recruiting
For-uveal mel, monosomy 3 positive, no mets.  Drug = autologous dendritic cells




Recruiting
NY-ESO-1 Vaccine in Combination With Ipilimumab in Patients With Unresectable or Metastatic Melanoma NCT01810016 For-unresectable mel.  Drug = ipi, NY-ESO-1protein vaccine, NY-ESO-1OLP4 vaccine




Recruiting
NCT01970358 For-mel, Drug = poly-ICLC peptides




Recruiting
Trial of Ipilimumab After Isolated Limb Perfusion, in Patients With Metastases Melanoma NCT02094391 For-in-transit mel Stage IIIB and IIIC. Drug = ipi




Recruiting




Recruiting
{NOTE – my trial….peptide vaccines no longer given}




Recruiting




Recruiting
NCT01308294. For-mel, Drug = vaccine




Recruiting




Recruiting




Recruiting
CDX-1401 and Poly-ICLC Vaccine Therapy With or Without CDX-301in Treating Patients With Stage IIB-IV Melanoma NCT02129075 For-ciliary body, choroid, extraocular, iris, intraocular, mucosal mel or melanoma Stage IIB – IV Drug = recombinant flt3 ligand, vaccine




Recruiting
NCT01838200 For-metastatic mel, Drug = BCG vaccine, ipi




Recruiting
Vaccine Therapy With or Without Interleukin-12 Followed by Daclizumab in Treating Patients With Metastatic Melanoma NCT01307618 For-recurrent mel, stageIV.  Drug = peptide vaccine, MAGE-3.1 antigen, interleukin-12, Mart-1 antigen




Recruiting
Trial of pIL-12 Electroporation Malignant Melanoma NCT01502293 For-mel, Drug=Plasmid interleukin-12




Recruiting






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