Tuesday, June 14, 2016

Adoptive cell therapy with CTLA4 induces remission in patient resistant to both modalities given serially and individually

This is one patient....

Combined IL-21-primed polyclonal CTL plus CRLA4 blockade controls refractory metastatic melanoma in a patient.  Chapuis, Lee, Thompson, et al.  J Exp Med. 2016 May 30. 

Adoptive transfer of peripheral blood-derived, melanoma-reactive CD8+ cytotoxic T lymphocytes (CTLs) alone is generally insufficient to eliminate bulky tumors. Similarly, monotherapy with anti-CTLA4 infrequently yields sustained remissions in patients with metastatic melanoma. We postulated that a bolus of enhanced IL-21-primed polyclonal antigen-specific CTL combined with CTLA4 blockade might boost antitumor efficacy. In this first-in-human case study, the combination successfully led to a durable complete remission (CR) in a patient whose disease was refractory to both monoclonal CTL and anti-CTLA4. Long-term persistence and sustained anti-tumor activity of transferred CTL, as well as responses to nontargeted antigens, confirmed mutually beneficial effects of the combined treatment. In this first-in-human study, Chapuis et al. demonstrate that the combination of adoptive cellular therapy with CTLA4 blockade induces long-term remission in a melanoma patient resistant to both modalities administered serially and individually.

For what it is worth - c


  1. I wonder how similar to trial I'm looking with MD Anderson this is. Wonder if this patient had to be HLA-A201 positive...that's what I'm waiting on...another blood test.

    1. I don't think that this was really a trial....though not sure...but rather a case report of what was tried with this one, individual patient.