We've long known that higher vitamin D levels provide a better prognosis in melanoma. Here is a link (with others within) discussing Vitamin D: Vitamin D and melanoma - folks with higher levesl do better - again!!!
Now there is this ~
On the role of classical and novel forms of vitamin D in melanoma progression and management. Slominski, Brozyna, Skobowiat, et al. J Steroid Biochem Mol Biol. 2017 Jul 1.
Melanoma
represents a significant clinical problem affecting a large segment
of the population with a relatively high incidence and mortality
rate. Ultraviolet radiation (UVR) is an important etiological factor
in malignant transformation of melanocytes and melanoma development.
UVB, while being a full carcinogen in melanomagenesis, is also
necessary for the cutaneous production of vitamin D3 (D3). Calcitriol
(1,25(OH)2D3) and novel CYP11A1-derived hydroxyderivatives
of D3 show anti-melanoma activities and protective properties against
damage induced by UVB. The former activities include inhibitory
effects on proliferation, plating efficiency and
anchorage-independent growth of cultured human and rodent melanomas
in vitro, as well as the in vivo inhibition of tumor growth by
20(OH)D3 after injection of human melanoma cells into immunodeficient
mice. The literature indicates that low levels of 25(OH)D3 are
associated with more advanced melanomas and reduced patient
survivals, while single nucleotide polymorphisms of the vitamin D
receptor or the D3 binding protein gene affect development or
progression of melanoma, or disease outcome. An inverse correlation
of VDR and CYP27B1 expression with melanoma progression has been
found, with low or undetectable levels of these proteins being
associated with poor disease outcomes. Unexpectedly, increased
expression of CYP24A1 was associated with better melanoma prognosis.
In addition, decreased expression of retinoic acid orphan receptors α
and γ, which can also bind vitamin D3 hydroxyderivatives, showed
positive association with melanoma progression and shorter
disease-free and overall survival. Thus, inadequate levels of
biologically active forms of D3 and disturbances in expression of the
target receptors or D3 activating or inactivating enzymes, can affect
melanomagenesis and disease progression. We therefore propose that
inclusion of vitamin D into melanoma management should be beneficial
for patients, at least as an adjuvant approach. The presence of
multiple hydroxyderivatives of D3 in skin that show anti-melanoma
activity in experimental models and which may act on alternative
receptors, will be a future consideration when planning which forms
of vitamin D to use for melanoma therapy.
For what it's worth! - c
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