Me and Bubba, man! "... like I was sayin', shrimp is the fruit of the sea. You can barbecue it, boil it, broil it, bake it, saute it. There's uh, shrimp-kabobs, shrimp creole, shrimp gumbo. Pan fried, deep fried, stir-fried. There's pineapple shrimp, lemon shrimp, coconut shrimp, pepper shrimp, shrimp soup, shrimp stew, shrimp salad, shrimp and potatoes, shrimp burger, shrimp sandwich. That- that's about it." ~ Forest Gump
Who knew those little shrimpies could demonstrate another route through which to target and defeat melanoma?????
Shrimp
miR-S8 suppresses the stemness of human melanoma stem-like cells by
targeting the transcription factor YB-1. Yang, Wei, Shang, et al. Cancer
Res. 2017 Aug 30.
Cross-species
regulation of gene expression by microRNA is a possible untapped
opportunity for miRNA-based therapy. In this study, we report a novel
approach to ablate melanoma stem-like cells by targeting the
transcription factor YB-1, which is significantly and selectively
upregulated in these cells in melanoma. Silencing YB-1 expression was
sufficient to significantly inhibit the stemness of melanoma
stem-like cells. In exploring YB-1 targeting, we discovered that the
shrimp microRNA miR-S8 could suppress human YB-1 expression in
melanoma stem-like cells. Mechanistic investigations revealed that
miR-S8 recognized the 3'UTR of YB-1 mRNA and mediated its
degradation. In tumor cell and xenograft experiments, miR-S8
suppressed the tumorigenic capacity of melanoma stem-like cells by
targeting human YB-1. Overall, our results illuminated a novel aspect
of miRNA-mediated cross-species gene expression and its use in
regulating cancer stem-like cells.
Oh, yeah!! If this works out....I'll really be like'n some shrimp!!! - c
many thanks for information. So I will add up more shrimps to my weekly diet. I love them boiled and putted in a virgin olive oil.
ReplyDeleteSounds good to me!!!
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