tag:blogger.com,1999:blog-5986812882047614235.post4684831400787493317..comments2024-01-15T13:54:44.833-05:00Comments on Chaotically Precise: Life, Love, and Melanoma: ASCO 2015: New trial for melanoma brain mets!!! Ipi and Nivo, followed by Nivo alone (CheckMate 204) Leshttp://www.blogger.com/profile/07988740020076170293noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-5986812882047614235.post-64369249513231970772015-06-23T22:05:14.904-04:002015-06-23T22:05:14.904-04:00Ultimately this decision/definition is up to the t...Ultimately this decision/definition is up to the trial co-ordinator/researcher. However, it sounds as though patients enrolling need to have a normal neurologic exam with no overt neurologic symptoms....ie: seizures, one sided weakness, cognitive dysfunction, etc. Neither fatigue nor loss of appetite are specific neurologic signs.Leshttps://www.blogger.com/profile/07988740020076170293noreply@blogger.comtag:blogger.com,1999:blog-5986812882047614235.post-18012127828038193692015-06-23T15:29:19.781-04:002015-06-23T15:29:19.781-04:00Any idea what specifically is meant by, "Subj...Any idea what specifically is meant by, "Subjects must be free of neurologic signs and symptoms related to metastatic brain lesions"? It seems like it could mean just cognitive or sensory deficits, or it could include symptomatic (extraordinary) fatigue and loss of appetite.Anonymoushttps://www.blogger.com/profile/04348675433724005099noreply@blogger.com