tag:blogger.com,1999:blog-5986812882047614235.post5133722176436272059..comments2024-01-15T13:54:44.833-05:00Comments on Chaotically Precise: Life, Love, and Melanoma: Anti-PDL1 for melanoma: A Phase 1 trial of MEDI4736 in Combination With Dabrafenib and Trametinib or With Trametinib AloneLeshttp://www.blogger.com/profile/07988740020076170293noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-5986812882047614235.post-45228903105600575592015-12-21T19:48:32.517-05:002015-12-21T19:48:32.517-05:00It is very interesting and hopeful as these cancer...It is very interesting and hopeful as these cancers reveal their overlap. Hopefully treatments and cures will do the same. Hope MEK serves this patient well!!! Glad my post was of some help via an explanation at least.Leshttps://www.blogger.com/profile/07988740020076170293noreply@blogger.comtag:blogger.com,1999:blog-5986812882047614235.post-30007343318732639452015-12-20T09:24:11.662-05:002015-12-20T09:24:11.662-05:00I bet you get comments on years old posts all the ...I bet you get comments on years old posts all the time. A caregiver who posts on behalf of her father on the bladder cancer advocacy network site recently broke the news that he has been pulled out of the same Nivolumab trial that I am in. His liver mets have been unaffected in the trial and he's had what dr believes is some non-pseudo progression. <br />Fortunately, our principal trial dr (a hematologist/oncologist), had sent off a liver met biopsy to Foundation One. There they determined the cancer cells actually were positive for BRAF mutations (not V600e). Mekinist alone was recommended. An application to a a company called Novartis was granted and her father will be given a hopeful regimen of this drug. I'm very hopeful and encouraged that this has all sprouted from an immunology trial, and the my (our) doc is using resources to try and find an inhibitor that matches her fathers mets. If this works for him in any way, it's an example of modern target therapy in action. Mekinist for BC due to the presence of BRAF is a new one to me but I am optimistic<br />Of course, solid information on Mekinist and its history were as available and well-explained on your blog as anyplace out there. You're awesome!Anonymoushttps://www.blogger.com/profile/05941357428978551250noreply@blogger.comtag:blogger.com,1999:blog-5986812882047614235.post-24297838095882522652015-12-19T12:07:58.621-05:002015-12-19T12:07:58.621-05:00This comment has been removed by the author.Anonymoushttps://www.blogger.com/profile/05941357428978551250noreply@blogger.com