tag:blogger.com,1999:blog-5986812882047614235.post107605835950750464..comments2024-01-15T13:54:44.833-05:00Comments on Chaotically Precise: Life, Love, and Melanoma: Expanded Access for ipi/Nivo combo and Nivo/Opdivo Licensing Application????Leshttp://www.blogger.com/profile/07988740020076170293noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-5986812882047614235.post-73966757320264653512014-07-13T13:18:10.039-04:002014-07-13T13:18:10.039-04:00KG: So sorry for such unfortunate side effects an...KG: So sorry for such unfortunate side effects and having to stop the treatment. However, that is a wonderful response and I have hope that the stability will be maintained for a long time. I just posted more data about the combo trial that your husband serves as a living example of!!! (With additional data that Rick may be interested in as well.) So glad he is living life LARGE. My best to you both. Ratties are AWESOME!!!Leshttps://www.blogger.com/profile/07988740020076170293noreply@blogger.comtag:blogger.com,1999:blog-5986812882047614235.post-14163082741329392552014-07-13T10:27:10.204-04:002014-07-13T10:27:10.204-04:00Update on my husbands results from his participati...Update on my husbands results from his participation in the Ipi/PD1 clinical trial: started early 11/13 stopped treatment 12/28/13 due to grade 4 A/E's. Still monitored as part of the trial but no further treatment allowed. Results: >80% reduction of softball size tumors in his abdomen -remain stable. Lung mets almost imperceptible. Permanent side effects: insulin dependent diabetes; neuropathy and vitigilo. He's living life with it! Playing softball at the moment with our 21 year old twins (needs a designated runner). May leave the trial soon. Will be interesting to know if he had the combo. Suspect he did. Thanks for posting all the data. KGhttps://www.blogger.com/profile/05632494612809017169noreply@blogger.comtag:blogger.com,1999:blog-5986812882047614235.post-68242491715881810732014-07-11T15:05:00.112-04:002014-07-11T15:05:00.112-04:00What was presented at this year's ASCO meeting...What was presented at this year's ASCO meeting was just an update on the study that is ongoing from 2013...you can click on the link in the above post to my June 2013 post "Ipi and Nivolumab, better together??" for the details they put out. The patients were all melanoma patients but it does briefly address prior therapies and responses based on the various doses used. Yes, only in melanoma world is a response rate around 40% and a survival rate of 79% at 2 years, with a median survival of 3-4 years, great news. However, in an interview Weber gave after ASCO this year, he did talk about how impressed he and Sznol had been with the "steep responses" many patients experienced along with an 80% rate for tumor regression. He also noted that BRAF status (whether you were BRAF positive or not) made no difference in response when patients were given this combo, nor did the presence of PDL1 seem to affect the results. One unknown that may change the results of the patients that get this current EAP version of nivo and ipi....is the fact that they must be ipi and nivo naive. Some of the patients in the study from which this data was gleaned had already had ipi. It seems that more and more experts (see the discussion around LAG3 a few posts back) are of the opinion that once treated with an immune therapy, the response to subsequent immune therapies is not as high. Multiple studies have born that out, sadly. However, if that is so, patients in this EAP cohort could, conceivably, have better responses than this data demonstrates. Hope that helps. Yours, LesLeshttps://www.blogger.com/profile/07988740020076170293noreply@blogger.comtag:blogger.com,1999:blog-5986812882047614235.post-38466039369061975522014-07-11T12:46:47.706-04:002014-07-11T12:46:47.706-04:00great news! do you have the response rate of nivol...great news! do you have the response rate of nivolumab/opdivo per cancer type/stage, age group, gender, etc from earlier ASCO or similar presentations? 40% is still scary!Anonymoushttps://www.blogger.com/profile/14553794762606065521noreply@blogger.com